Status:
TERMINATED
Assessment of Metabolic Response in Critically Ill Patients With Acute Renal Failure
Lead Sponsor:
Vanderbilt University
Conditions:
Acute Renal Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to...
Eligibility Criteria
Inclusion
- Adults ≥ 18 years of age admitted to the intensive care unit
- New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease
- ARF will be defined by a sustained (over 24 hours) increase in serum creatinine \> 0.5 mg/dl from baseline
- Patients will be recruited for the study within 3-5 days following establishment of ARF
Exclusion
- Institutionalized patient
- Previous kidney transplant
- Pregnancy
- Unable to obtain consent from subject or legally recognized representative
- ARF from urinary tract obstruction or a volume responsive pre-renal state.
- Liver Failure
- Recent cerebrovascular accident (CVA)
- Coagulopathy defined as: Platelets \< 50, PT \> 20, INR \> 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion.
- Life expectancy \< 48 hours
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2005
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00179166
Start Date
June 1 2004
End Date
July 1 2005
Last Update
September 27 2010
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37232