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Status:

COMPLETED

Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease

Lead Sponsor:

Technische Universität Dresden

Collaborating Sponsors:

Deutsche Parkinson-Vereinigung e.V.

MSE Pharmazeutika GmbH, Bad Homburg

Conditions:

Parkinson's Disease

Eligibility:

All Genders

40-75 years

Phase:

PHASE3

Brief Summary

This study was designed to evaluate the symptomatic effects of Coenzyme Q10 nanodispersed solution in middle-stage Parkinson's disease (PD) patients (Hoehn\&Yahr II to III). The treatment phase includ...

Detailed Description

This study was designed to evaluate the symptomatic effects of Coenzyme Q10 nanodispersed solution in middle-stage non-fluctuating Parkinson's disease (PD) patients (Hoehn\&Yahr II to III). The treatm...

Eligibility Criteria

Inclusion

  • Parkinson's disease according to the UK Brain Bank criteria
  • Hoehn \& Yahr stadium II until III
  • Male or female
  • Age 40 to 75 years
  • UPDRS Part III \> 15 points
  • No motor fluctuations or dyskinesias
  • Stable parkinsonian condition for 4 weeks prior to inclusion
  • Outpatients
  • Patients without or with stable levodopa treatment for 4 weeks prior inclusion
  • Written informed consent

Exclusion

  • Atypical or drug-induced parkinsonian syndromes
  • Dyskinesias or motor fluctuations
  • Coenzyme Q10 treatment in the past
  • Pregnancy
  • Epileptic seizures in the history
  • Hypothyroidism
  • Severe medical conditions with interference with study drug
  • Treatment with CSE inhibitors, thyroidal hormones, antiarrhythmic drugs, warfarin, metformin
  • Treatment or intake of vitamins, magnesium, vitamin E, calcium

Key Trial Info

Start Date :

September 1 2003

Trial Type :

INTERVENTIONAL

End Date :

June 1 2005

Estimated Enrollment :

132 Patients enrolled

Trial Details

Trial ID

NCT00180037

Start Date

September 1 2003

End Date

June 1 2005

Last Update

January 19 2009

Active Locations (13)

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Page 1 of 4 (13 locations)

1

Department of Neurology, University of Ulm

Ulm, Baden-Wurttemberg, Germany, 89081

2

Department of Neurology, Fachklinik Ichenhausen

Ichenhausen, Bavaria, Germany, 89335

3

Department of Neurology, Leopoldina Krankenhaus

Schweinfurt, Bavaria, Germany, 97422

4

Department of Neurology, University of Marburg

Marburg, Hesse, Germany, 35039