Status:
COMPLETED
Inflammation and Corticosteroid Responsiveness in Severe Asthma
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Asthma
Eligibility:
All Genders
18-60 years
Brief Summary
Some patients with mild asthma may develop severe asthma. It is not known what makes patients with mild asthma become severe, and we plan to find out why this happens. Patients with severe asthma may ...
Detailed Description
Study Design Patients referred to the Royal Brompton Hospital with severe asthma will be entered into a protocol that will determine whether they have asthma, and if so, the severity and clinical feat...
Eligibility Criteria
Inclusion
- The final diagnosis of severe asthma will be made according to the screening steps we have set up. The definition will require the presence of one or both major criteria (treatment with continuous or near continuous oral corticosteroids and/or requirement for treatment with high dose inhaled steroids) and two minor criteria.
- Patients who do not fit the criteria of severe asthma will not be entered into the study.
- Age 18-60; both sexes.
- For the investigation of fiberoptic bronchoscopy, other additional inclusion criteria will be imposed:
- Post-bronchodilator FEV1 greater than 40% on the day of the bronchoscopy
- No evidence of an exacerbation of asthma within the past 4 weeks.
- Ability to cooperate with procedures
- Ability to give consent
- Current smokers, and ex-smokers with greater than 10 pack years history of smoking.
- Exclusion criteria
- Pregnancy or unreliable contraceptive measures in child-bearing woman. he bronchoscopist has determined the subject is clinically appropriate for bronchoscopy
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Exclusion
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Key Trial Info
Start Date :
August 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT00180661
Start Date
August 1 2003
End Date
May 1 2008
Last Update
October 4 2019
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6HP