Status:
TERMINATED
Canadian Pulmonary Embolism Diagnosis Study (CANPEDS)
Lead Sponsor:
Hamilton Health Sciences Corporation
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Suspected Pulmonary Embolism
Deep Venous Thrombosis
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
The main objective of the trial is to determine whether D-dimer testing combined with assessment of Pre-Test-Probability (using a standardized clinical model) can be used to markedly simplify the diag...
Detailed Description
To assess the value of the D-dimer in the diagnosis of PE, we had two sub-groups of patients with suspected PE, low and high pre-test probability. Patients could be randomized either to further or no ...
Eligibility Criteria
Inclusion
- Patients with clinically suspected PE
Exclusion
- Treatment with anticoagulants for greater than 24 hours of performance of D-d
- Comorbid condition limiting survival to less than 3 months
- Absence of acute symptoms within 7 days prior to presentation
- Current pregnancy
- Contraindication to contrast (e.g., allergy, renal failure)
- Geographic inaccessibility which precludes follow-up
- Physician believes patient is inappropriate for study
- failure or inability to provide informed consent
Key Trial Info
Start Date :
August 1 1998
Trial Type :
INTERVENTIONAL
End Date :
January 1 2001
Estimated Enrollment :
1126 Patients enrolled
Trial Details
Trial ID
NCT00182546
Start Date
August 1 1998
End Date
January 1 2001
Last Update
May 3 2006
Active Locations (7)
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1
Queen Elizabeth II Health Sciences Ctr.
Halifax, Nova Scotia, Canada, B3H 1V7
2
Alexander G. Turpie
Hamilton, Ontario, Canada, L8L 2X2
3
McMaster University Medical Centre
Hamilton, Ontario, Canada, L8N 3Z5
4
James Douketis
Hamilton, Ontario, Canada, L8N 4A6