Status:
COMPLETED
Donepezil in Preventing Delirium in Hospitalized Elderly
Lead Sponsor:
Indiana University Health
Conditions:
Postoperative Complications
Delirium
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.
Detailed Description
Delirium is confusion or a sudden change in alertness which may happen after hip repair surgery. Up to 65% of elderly undergoing surgical repair of hip fracture experience post-operative delirium. The...
Eligibility Criteria
Inclusion
- Community-dwelling individuals aged 65 or older
- Admitted to Methodist Hospital for surgical repair of hip fracture
- No evidence of delirium at admission to hospital
- MMSE total score below 24 points after adjustment for education and age
- Consent to participate in the study
Exclusion
- Severely demented as defined by MMSE score below 10
- Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months
- Multiple trauma or pathological fractures
- Aphasic, legally blind, or deaf
- Use of Donepezil or other cholinesterase inhibitors within one month prior to surgery
- Allergy to Donepezil
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00182884
Start Date
July 1 2004
End Date
April 1 2007
Last Update
March 3 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Methodist Hospital, Clarian Health Partners
Indianapolis, Indiana, United States, 46202