Status:
COMPLETED
Effects of Dehydroepiandrosterone (DHEA) in Humans
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Aging
Eligibility:
All Genders
65-75 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether bringing back the DHEA levels of older persons to the young range produces beneficial effects.
Detailed Description
DHEA and DHEA sulfate (DHEAS) plasma concentrations peak at about 20 years of age and decline rapidly and markedly after age 25 yr. DHEA is a PPAR-alpha activator. PPAR-alpha plays major roles in regu...
Eligibility Criteria
Inclusion
- 65 to 75 years old
- Physically healthy
- Non-smoker
- On stable medications for at least 6 months
- Stable body weight for the past year
Exclusion
- Serious active medical problems
- Hormone therapy
- Abnormal PSA (prostate specific antigen) in men
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT00182975
Start Date
September 1 2002
End Date
September 1 2007
Last Update
August 25 2008
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63131