Status:
COMPLETED
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
Lead Sponsor:
Eric Lenze
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospita...
Detailed Description
Depression is a serious medical illness that is often difficult to diagnose and treat. It occurs in people of all ages, but is often overlooked in older adults. Depression frequently co-occurs with ot...
Eligibility Criteria
Inclusion
- Admission to a skilled nursing facility for rehabilitation within 3 months of recent disabling medical event (e.g., hip fracture)
- Medically stable (e.g., no active seizures, delirium, unstable pulse/blood pressure)
Exclusion
- Aphasia or cognitive impairments sufficiently severe to prevent valid assessment (e.g., a score of less than 22 on the Mini Mental State Examination)
- Current major depressive episode
- History of or current psychosis or mania
- Current substance or alcohol abuse or dependence (within 3 months of study entry)
- Current use of memantine
- Sensitivity or contraindication to memantine
- End-stage kidney, liver, heart, or lung disease
- Recent hemorrhagic stroke
- A FIM score of greater than 70 (on a 91 point scale)
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00183729
Start Date
August 1 2005
End Date
June 1 2009
Last Update
January 17 2018
Active Locations (1)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213