Status:
COMPLETED
Understanding Brain Reward Responses in Individuals With Major Depressive Disorder
Lead Sponsor:
Mclean Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression
Eligibility:
All Genders
18-64 years
Brief Summary
This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD).
Detailed Description
Major depressive disorder (MDD) is a severe form of depression that can significantly interfere with an individual's thoughts, behavior, mood, and physical health. People who suffer from MDD may exper...
Eligibility Criteria
Inclusion
- Overall
- Right-handed
- Agrees to use an effective form of contraception throughout the study
- Inclusion Criteria for Depressed Participants:
- Meets overall inclusion criteria
- Meets DSM-IV diagnosis criteria for major depressive disorder
- Score of at least 16 on the 21-item HAM-D scale
- Overall
Exclusion
- Left-handed or ambidextrous
- Claustrophobic
- Neurological or medical illness (e.g., attention deficit hyperactivity disorder, head injury, loss of consciousness, seizures)
- Pregnant
- Exclusion Criteria for Depressed Participants:
- Meets any of the overall exclusion criteria
- Has been treated with electroconvulsive therapy within 6 months of study entry
- Has taken any benzodiazepine medications for at least 2 weeks prior to study entry and discontinued use of the medication for reasons other than participating in the study
- Has taken any dopaminergic medications (including methylphenidate) or neuroleptics for at least 6 months prior to study entry and discontinued use of the medication for reasons other than participating in the study
- Has taken any fluoxetine medications for at least 6 weeks prior to study entry and discontinued use of the medication for reasons other than participating in the study
- Has taken any medications that may have antidepressant properties (including some herbal supplements) within 2 weeks of study entry
- Has taken any medications that may affect blood flow (including some blood pressure medications) within 2 weeks of study entry
- Current or past history of MDD with psychotic features
- Meets DSM-IV diagnosis criteria for organic mental disorder; substance use disorder (within 1 year of study entry); lifetime substance dependence; schizophrenia; delusional disorder; bipolar disorder; post-traumatic stress disorder; eating disorder; acute bereavement; severe borderline or antisocial personality disorder; or any psychotic disorder not otherwise specified
- Current primary diagnosis of panic disorder, social phobia, generalized anxiety disorder, obsessive-compulsive disorder, or somatoform disorder
- Exclusion Criteria for Control Participants
- Meets any of the overall exclusion criteria
- Diagnosed with any medical or neurological illness
- Diagnosed with any current or past psychiatric illness, as assessed by the SCID-I, including substance abuse or dependence (e.g., alcohol)
- Has taken any medications that may have antidepressant properties (including some herbal supplements) within 2 weeks of study entry
- Has taken any psychotropic medications within 2 weeks of study entry
- Has taken any medications that may affect blood flow (including some blood pressure medications) within 2 weeks of study entry
- Exclusion Criteria for fMRI Studies:
- Meets any of the overall exclusion criteria
- Fails to meet safety standards for fMRI
- Current back problems
- Has strongly corrected vision, but does not wear contact lenses
- Weighs more than 250 pounds or exceeds the limit of height-to-weight ratio for a comfortable fit in the scanner
- Pregnant
- Current alcohol or substance abuse
- At risk for suicide or homicide
Key Trial Info
Start Date :
April 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT00183755
Start Date
April 1 2005
End Date
April 1 2009
Last Update
April 21 2014
Active Locations (3)
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1
The Depression Clinical and Research Program, Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Affective Neuroscience Laboratory, Department of Psychology, Harvard University
Cambridge, Massachusetts, United States, 02138
3
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129