Status:
COMPLETED
Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users
Lead Sponsor:
Butler Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
HIV Infections
Depression
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
This study will evaluate the effectiveness of combining cognitive behavioral therapy (CBT) and antidepressants in reducing HIV risk behavior and drug relapse rates in depressed intravenous drug users.
Detailed Description
Depression is common among injection drug users (IDUs); it is estimated that up to 50% of IDUs meet the diagnostic criteria for major depressive disorder, a severe form of depression. The combination ...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for major depression, dysthymia, substance-induced major depression, or major depression plus dysthymia
- Score of greater than 14 on the Hamilton Depression Rating Scale
- Involved in HIV risk behaviors
- Current opiate or cocaine use
- Basic proficiency in English
Exclusion
- Current suicidal risk or ideation
- Current psychotic symptoms
- Simultaneous medical disorder that might make psychopharmacological treatment medically inadvisable
- History of bipolar disorder, schizophrenia, schizo-affective disorder, schizophreniform disorder, or paranoid disorder
- Currently taking other medications for depression
Key Trial Info
Start Date :
September 1 1999
Trial Type :
INTERVENTIONAL
End Date :
February 1 2003
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT00183768
Start Date
September 1 1999
End Date
February 1 2003
Last Update
August 22 2013
Active Locations (1)
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1
Rhode Island Hospital
Providence, Rhode Island, United States, 02903