Status:
COMPLETED
Ischemic Injury and Ischemic Preconditioning in Diabetes
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Dutch Diabetes Fund
Conditions:
Diabetes Mellitus, Insulin-Dependent
Ischemia-Reperfusion Injury
Eligibility:
All Genders
18-50 years
Brief Summary
In this proof-of-concept study, forearm vulnerability to ischemic exercise is studied in patients with type 1 diabetes mellitus with and without prior ischemic preconditioning (short period of ischemi...
Detailed Description
All patients will be studied in supine position after an overnight fast, while plasma glucose levels are monitored. In the first 8 patients intravenous insulin is administered as needed, to reach targ...
Eligibility Criteria
Inclusion
- type 1 diabetes mellitus
- age 18-50 years
Exclusion
- hypertension (systolic blood pressure \> 140 mmHg and/or diastolic blood pressure \> 90 mmHg
- cardiovascular disease (coronary artery insufficiency,CVA/TIA, peripheral artery disease
- HbA1c \> 9%
- Body Mass Index \< 25 kg/m2
- Unable to stop co-medication (other than insulin) for 1 week
- Previous exposure to radiation (diagnostic or therapeutic) in the past year
Key Trial Info
Start Date :
June 1 2004
Trial Type :
OBSERVATIONAL
End Date :
May 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00184821
Start Date
June 1 2004
End Date
May 1 2005
Last Update
April 5 2007
Active Locations (1)
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1
Clinical Research Centre Nijmegen; Radboud University Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6500 HB