Status:
COMPLETED
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
Lead Sponsor:
Stanford University
Collaborating Sponsors:
University of Toronto
University of Colorado, Denver
Conditions:
Sepsis
Relative Adrenal Insufficiency
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not r...
Detailed Description
Severe sepsis is characterized by inadequate perfusion of vital organs due to infection. More than 750,000 cases of severe sepsis occur each year in the United States. Mortality among patients with se...
Eligibility Criteria
Inclusion
- Admission Diagnosis of Sepsis
- Evidence of Relative Adrenal Insufficiency
- Hypotension (Mean Arterial Pressure less than 60 mm Hg) Refractory to a. Fluid Resuscitation b. Dopamine infusion (greater than 5 micrograms/kg/min) c. Phenylephrine infusion (greater than 1 microgram/kg/min)
Exclusion
- Use of Immunosuppressant Medications
- Immune Compromised Due to Disease (e.g., HIV infection)
- Transfusion of Blood Products within the past 7 Days
- Use of Cytokine Therapy (i.e., G-CSF)
- History of Bone Marrow Transplantation
Key Trial Info
Start Date :
March 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2006
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00185783
Start Date
March 1 2005
End Date
November 1 2006
Last Update
April 11 2011
Active Locations (1)
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1
Stanford University Medical Center
Stanford, California, United States, 94305