Status:
COMPLETED
BNP for Cardio-Renal Decompensation Syndrome (BNP-CARDS)
Lead Sponsor:
Stanford University
Collaborating Sponsors:
Scios, Inc.
Conditions:
Congestive Heart Failure Exacerbation
Renal Insufficiency
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Many patients with exacerbations of heart failure have significant concomitant kidney dysfunction. The combination of these two conditions makes pharmacological management difficult. In this study, we...
Detailed Description
Heart failure represents a growing epidemic in the United States. Recent figures reveal that almost 5 million people have heart failure in the U.S. alone, with an incidence (550,000 new diagnoses/year...
Eligibility Criteria
Inclusion
- acute admission to hospital with CHF exacerbation
- calculated creatinine clearance between 15-60ml/min using the Cockroft Gault equation.
Exclusion
- hypotension (SBP \< 90mmHg)
- hypertension (SBP \> 170 mmHg) necessitating vasodilator therapy
- known allergy to Natrecor
- history of heart transplantation
- contraindications to vasodilator therapy (i.e. severe aortic stenosis)
- up-front use of inotropes
- mental incompetence meaning inability to provide informed consent
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
October 1 2006
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00186329
Start Date
March 1 2004
End Date
October 1 2006
Last Update
April 28 2015
Active Locations (1)
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1
Stanford University Medical Center
Stanford, California, United States, 94305