Status:
WITHDRAWN
How Airway Remodeling and Hyperresponsiveness Contribute to Airflow Obstruction in Asthma
Lead Sponsor:
St. Joseph's Healthcare Hamilton
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Asthma
Eligibility:
All Genders
18-65 years
Brief Summary
Airway hyperresponsiveness is a characteristic feature of the asthma. It is known that there is an association between airway hyperresponsiveness and eosinophilic airway inflammation. However, even th...
Detailed Description
Airway hyperresponsiveness (AHR) is a characteristic feature of the asthmatic condition in humans. There is an association between AHR and eosinophilic airway inflammation. However, even though eosino...
Eligibility Criteria
Inclusion
- Inclusion/ Exclusion Criteria:
- adults age 18 - 65 years
- stable asthma, defined as no need for new medical intervention in previous 4 weeks
- pre FEV1 \> or = to 70% and able to have a methacholine challenge
- hyper-responsiveness as measured by methacholine challenge PC20 \< or = 16 mg/ml
- steroid naive or stable inhaled corticosteroid medication in previous 8 weeks
- symptomatic treatment with bronchodilators permitted
- able to give written informed consent
- no other active/unstable medical conditions as judged by investigator
- subjects must be suitable for bronchoscopy in opinion of the investigator
- female subjects must no be pregnant, nursing or unwilling to use appropriate contraception
Exclusion
Key Trial Info
Start Date :
September 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00186693
Start Date
September 1 2006
End Date
June 1 2009
Last Update
July 26 2011
Active Locations (1)
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1
St Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6