Status:
COMPLETED
Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
Lead Sponsor:
University of California, San Francisco
Conditions:
Diabetes Mellitus, Type 1
Eligibility:
All Genders
8-21 years
Phase:
NA
Brief Summary
The long-term effects of high blood sugar include blindness, kidney failure, and nerve damage that can ultimately cause loss of limbs. Research has shown that high blood sugar increases the amount of ...
Eligibility Criteria
Inclusion
- Subjects must be pubertal (defined as Tanner stage II or greater), or post-pubertal, with an upper age limit of 21 years.
- Subjects must have diabetes by 1997 ADA criteria:
- fasting plasma glucose \>= 126 mg/dL, or
- 2 hour postprandial glucose \>= 200 mg/dL
- Subjects must have history of least one auto-antibody associated with T1D, either glutamic acid decarboxylase (GADA) or islet cell autoantigen 512 (ICA512), or history of diabetic ketoacidosis.
Exclusion
- 1\. Subjects must not have history of eye, kidney or nerve damage 2. Subjects must not be deemed unable or unlikely to comply with the protocol. Children who are unable to swallow pills, or are unwilling to take pills twice daily will be excluded from the study.
- \-
Key Trial Info
Start Date :
August 1 2004
Trial Type :
INTERVENTIONAL
End Date :
October 1 2005
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00187564
Start Date
August 1 2004
End Date
October 1 2005
Last Update
May 6 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UCSF Division of Pediatric Endocrinology
San Francisco, California, United States, 94143-0434