Status:
COMPLETED
Impact of Genetics on Metformin Pharmacokinetics
Lead Sponsor:
University of California, San Francisco
Conditions:
Other Conditions That May Be A Focus of Clinical Attention
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Specific Aims: To compare metformin pharmacokinetics in monozygotic and dizygotic twin pairs. Comparing renal clearance of metformin in monozygotic and dizygotic twins will allow us to better understa...
Detailed Description
Twin studies have long been a valuable tool for examining the relative role of environment and heredity in health issues such as disease and drug response. For example, twin studies in the 1960's and ...
Eligibility Criteria
Inclusion
- Part of either a monozygotic or dizygotic twin pair.
- Healthy (by medical history and laboratory values).
- Between 18 and 40 years old.
Exclusion
- Taking regular medication other than vitamins.
- Individuals with anemia (hemoglobin \< 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL Pregnant at time of study.
- Diagnosis of hypoglycemia, phlebitis and/or stroke will be excluded.
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00187798
Start Date
August 1 2001
End Date
July 1 2007
Last Update
September 25 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California San Francsico
San Francisco, California, United States, 94143