Status:
COMPLETED
Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Lead Sponsor:
University Hospital, Angers
Collaborating Sponsors:
Ministry of Health, France
Conditions:
Acute Respiratory Distress Syndrome
Acute Lung Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of this multicenter randomized controlled trial is to compare the impact on mortality of patients mechanically ventilated for acute lung injury or acute respiratory distress syndrome of two st...
Detailed Description
Most patients suffering from acute lung injury or acute respiratory distress syndrome require mechanical ventilation. In this setting, positive end-expiratory pressure is used to improve arterial oxyg...
Eligibility Criteria
Inclusion
- Mechanical ventilation through an endotracheal tube
- Bilateral infiltrates consistent with pulmonary edema
- PaO2/FiO2 \< 300 mmHg
- No clinical evidence of left atrial hypertension. If measured, pulmonary artery occlusion pressure \< 18 mmHg
- Criteria 1, 2 et 3 jointly present for less than 48 hours
- Written informed consent obtained from the patient or surrogate
Exclusion
- Age \< 18 years
- Pregnancy
- Expected duration of mechanical ventilation through an endotracheal tube \< 48 hours
- Participation in other trials within the previous 30 days
- Increased intracranial pressure
- Severe chronic respiratory disease
- Morbid obesity (weight \> 1kg/cm)
- Sickle cell disease
- Bone marrow transplant or chemotherapy-induced neutropenia
- Extended burns (\> 30 % total body surface area)
- Severe chronic liver disease (Child-Pugh score C)
- Pneumothorax
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2006
Estimated Enrollment :
768 Patients enrolled
Trial Details
Trial ID
NCT00188058
Start Date
September 1 2002
End Date
February 1 2006
Last Update
March 22 2019
Active Locations (46)
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1
General Hospital of Aix en Provence
Aix-en-Provence, France, 13616
2
South Hospital of Amiens
Amiens, France, 80054
3
University Hospital of Amiens
Amiens, France, 80054
4
University Hospital of Angers
Angers, France, 49033