Status:
UNKNOWN
Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Hyperalgesia
Pain
Eligibility:
MALE
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
The primary aim is to determine whether perioperative NMDA-receptor antagonism has differential effects on postoperative pain, hyperalgesia and morbidity in younger and older patients. In order to ach...
Detailed Description
The immediate postoperative period is associated with spontaneous pain and hyperalgesia, i.e., increased pain response (both intensity and duration) to normally painful stimuli following tissue injury...
Eligibility Criteria
Inclusion
- Able to read and write English;
- Age 18-59 or \>= 60 years;
- American Society of Anesthesiologists Class 1 to 3;
- Scheduled for elective radical prostatectomy;
- Body weight between 50-110 kg, body mass index (BMI) \<= 30.
Exclusion
- Significant central nervous system (CNS), respiratory, cardiac, hepatic, renal or endocrine dysfunction and/or any significant sequelae;
- Contraindications, allergies to, and/or past adverse reactions to opioid analgesics, amantadine or nonsteroidal anti-inflammatory drugs (NSAIDS);
- Current Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) Axis I disorder or cognitive dysfunction or history of this within the last year;
- History of epilepsy or other seizures;
- History of chronic pain of at least 6 months duration;
- History of long term opioid use for chronic pain of at least 6 months duration;
- History of long term use of amantadine or other antiparkinsonian drug;
- Ingestion of antitussive medication (dextromethorphan) within the 48 hours before surgery;
- History of alcohol or drug dependency/abuse of at least 6 months duration
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT00188383
Start Date
January 1 2004
End Date
December 1 2006
Last Update
March 14 2006
Active Locations (1)
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1
University Health Network
Toronto, Ontario, Canada, M5G 2C4