Status:
TERMINATED
A Study of the Use of Methotrexate in the Treatment of Chronic Idiopathic Urticaria
Lead Sponsor:
Barnsley Hospital
Conditions:
Urticaria
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria, compared with placebo
Detailed Description
Chronic idiopathic urticaria is thought to affect approximately 0.1% of the population. It can be very disabling and difficult to treat. Antihistamines are the only drugs licensed for treatment of urt...
Eligibility Criteria
Inclusion
- severe unremitting chronic idiopathic urticaria
- disease resistant to treatment with antihistamines
- aged 18 years or more
Exclusion
- predominant physical urticaria
- urticarial vasculitis
- any contraindication to the use of methotrexate, eg. pregnancy / breast feeding, women wanting to conceive or man wanting to father a child within 12 months of entry, use of drugs which interact, underlying medical conditions
- use of immunosuppressant within 4 weeks of entry
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00189878
Start Date
August 1 2003
End Date
August 1 2008
Last Update
February 19 2016
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