Status:
COMPLETED
Weekly Paclitaxel, Low-Dose Estramustine, and Carboplatin in the Treatment of Hormone Refractory Prostate Carcinoma
Lead Sponsor:
SCRI Development Innovations, LLC
Collaborating Sponsors:
Bristol-Myers Squibb
Conditions:
Prostate Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
In this trial we will investigate how this three-drug regimen may be improved, both with respect to efficacy and toxicity, by making some modifications in the dosing and schedule in the treatment of p...
Detailed Description
Upon determination of eligibility, patients will receive: Paclitaxel + Estramustine + Carboplatin Patients will receive weekly paclitaxel and low-dose estramustine, in combination with carboplatin a...
Eligibility Criteria
Inclusion
- Adenocarcinoma of the prostate not curable with local treatment
- Disease progression while receiving hormonal therapy
- Measurable or evaluable disease
- Previous treatment with a maximum of one prior chemotherapy regimen
- ECOG performance status 0, 1, or 2.
- Adequate bone marrow, liver and kidney function
- Able to comprehend the nature of this study and give written informed consent
Exclusion
- You cannot participate in this study if any of the following apply to you:
- Age \< 18 years
- History of treatment for an invasive malignancy within five years
- Significant heart disease
- Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
Key Trial Info
Start Date :
August 1 2000
Trial Type :
INTERVENTIONAL
End Date :
February 1 2007
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00193193
Start Date
August 1 2000
End Date
February 1 2007
Last Update
August 4 2010
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