Status:
COMPLETED
Bevacizumab and Erlotinib in the Treatment of Patients With Carcinoma of Unknown Primary Site
Lead Sponsor:
SCRI Development Innovations, LLC
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Neoplasms, Unknown Primary
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This trial will investigate the combination of bevacizumab, and erlotinib in patients with adenocarcinoma or poorly differentiated carcinoma of unknown primary site. Bevacizumab and erlotinib are rela...
Detailed Description
Upon determination of eligibility, patients will be receive: * Bevacizumab + Erlotinib
Eligibility Criteria
Inclusion
- To be included in this study, you must meet the following criteria:
- Carcinoma of unknown primary site confirmed by biopsy
- Measurable disease
- ECOG performance status must be 0-1
- Adequate bone marrow, liver and kidney
- Understand the nature of this study and give written informed consent.
Exclusion
- You cannot participate in this study if any of the following apply to you:
- Age\< 18 years
- May not have received EGFR inhibitors
- History of acute myocardial infarction within 6 months
- Clinically significant cardiovascular disease
- Moderate to severe peripheral vascular disease.
- History of stroke within 6 months
- History of abdominal fistula, perforation, or abscess within 6 months
- Active concurrent infections
- Serious underlying medical conditions
- Active brain metastases
- Women who are pregnant or lactating.
- PEG or G-tube
- Proteinuria
- Any nonhealing wound, ulcer, or bone fracture.
- Any clinical evidence or history of bleeding, clotting or coagulopathy
- Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
End Date :
January 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00193622
Start Date
April 1 2004
End Date
January 1 2009
Last Update
September 17 2010
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