Status:
COMPLETED
Continuous Temozolomide in Patients With Advanced or Metastatic Soft Tissue Sarcoma or Metastatic Breast Cancer
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Schering-Plough
Conditions:
Breast Cancer
Soft Tissue Sarcoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether treatment with temozolomide can effect the survival of patients with advanced breast cancer or soft tissue sarcoma.
Detailed Description
Because repeated dosing of temozolomide correlates with an improved response, which may be due to progressive depletion of the enzyme AT, our hope is that a daily oral schedule will be the most active...
Eligibility Criteria
Inclusion
- Patients must have either:
- Stage IV, microscopically-confirmed carcinoma of the breast with:
- Relapse or progression while receiving, or within 12 months of having received, an anthracycline-containing (doxorubicin or mitoxantrone) or taxane-containing (paclitaxel or docetaxel) regimen as either adjuvant treatment or therapy for advanced breast cancer, or
- Treatment to a maximum dose of anthracycline (e.g., greater than 450 mg/m2 of doxorubicin), or
- A dose-limiting toxicity from a taxane, or
- An ECOG performance status of 2.
- OR -
- Unresectable or metastatic, microscopically-confirmed soft tissue sarcoma, that is not amenable to treatment with Adriamycin or Ifosfamide due to:
- Poor cardiac reserve, or
- Poor performance status (ECOG performance status = 2) or
- Having failed treatment with Adriamycin or reached dose-limiting toxicity from chemotherapy.
- Patients must have histologic slides and/or blocks must be available for review.
- Patients must have measurable (bidimensionally) or evaluable disease.
- Patients must be 18 years old or older.
- Patients must have Karnofsky Performance Status greater than 70% (ECOG less than 2) at screen and on the first day of treatment.
- Patients must have a life expectancy more than 16 weeks.
- Patients must be informed consent must be obtained prior to enrollment.
- Patients must be more than 2 weeks from prior surgery; more than 3 weeks from radiation therapy to the pelvis, spine or long bones; more than 3 weeks from prior chemotherapy (more than 6 weeks for mitomycin C or nitrosureas), or more than 2 weeks from prior hormonal therapy.
Exclusion
- Granulocytes less than 1,500/mm3.
- Platelet count less than 100,000/mm3.
- Hemoglobin less than 10 gm/dl.
- Creatinine greater than 2.0 mg/dl.
- Total bilirubin greater than ULN (institutional upper limit of normal).
- Visceral crisis characterized by rapidly progressive hepatic or lymphangitic lung metastases (i.e. patients whose disease is beyond control).
- Medically unstable (i.e. with uncontrolled disease); diagnosis of other systemic cancer.
- Pregnancy or lactation; failure to employ adequate contraception.
- Uncontrolled CNS disease.
- Greater than 30% marrow previously irradiated.
- Psychological, familial, sociological or geographical conditions which do not permit weekly medical follow-up and compliance with the study protocol.
Key Trial Info
Start Date :
July 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00194766
Start Date
July 1 2000
End Date
December 1 2006
Last Update
November 14 2007
Active Locations (1)
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1
University of Washington/Seattle Cancer Care Alliance
Seattle, Washington, United States, 98109-1023