Status:
TERMINATED
Treatment With ATRA-IV and Depakote in Patients With Advanced Solid Tumor Malignancies
Lead Sponsor:
Weill Medical College of Cornell University
Conditions:
Solid Tumor Malignancies
Eligibility:
All Genders
21+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to find out the highest tolerated dose of Depakote in combination with liposome encapsulated all-trans retinoic acid (ATRA-IV) in patients with advanced solid tumor malign...
Detailed Description
To determine the maximum tolerated dose of Depakote in combination with liposome encapsulated all-trans retinoic acid (ATRA-IV) in patients with advanced solid tumor malignancies. This will be a 2-st...
Eligibility Criteria
Inclusion
- Patients with histologic confirmation of a solid tumor malignancy with clinical evidence of metastatic disease.
- Patients must have failed at least one standard therapy, if available, for their malignancy. Patients may be entered on the trial without prior therapy if there is no standard effective therapy available.
- No active brain metastases or epidural tumor.
Exclusion
- Concomitant administration of steroids.
- Irradiation or chemotherapy within 14 days of start of protocol.
- Evidence of another active cancer, except for non-melanoma, carcinoma of the skin and in-situ carcinoma of the cervix curatively treated, Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for greater than 5 years.
- Women who are pregnant or lactating. Women or men of reproductive age who are unwilling to use two forms of effective contraception.
- Patients with clinically significant cardiac, renal or hepatic disease; severe debilitating pulmonary disease; or history of diabetes mellitus prone to ketoacidosis.
- Patients with a history of pancreatitis.
- Patients with known hypersensitivity to retinoids or retinoic acid derivatives.
- Patients with coagulation disorders, such as thrombophlebitis or pulmonary embolism.
- Patients with pre-existing psychiatric condition, especially depression or a history of severe uncontrolled psychiatric disorder.
- Patients with pre-existing thyroid abnormalities whose thyroid function cannot be maintained in the normal range.
- Patients with chronic moderate to severe nausea.
- Patients with history of epilepsy or a seizure disorder taking anti-convulsant medication.
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00195156
Start Date
July 1 2003
Last Update
September 14 2006
Active Locations (1)
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1
Weill Medical College of Cornell University
New York, New York, United States, 10021