Status:
COMPLETED
Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia
Lead Sponsor:
Goethe University
Conditions:
Adult Acute Lymphocytic Leukemia
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
The aim of this study is to test feasibility and efficacy of a dose reduced chemotherapy in elderly patients with newly diagnosed acute lymphoblastic leukemia. The regimen consists of induction phase ...
Eligibility Criteria
Inclusion
- diagnosis of acute lymphoblastic leukemia (pro-B,common,pre-B,pre-T,Thy-,mature T, B-ALL)
- age \> 65 years
- written informed consent
- Karnofsky \> 50% (if not mainly caused by leukemia)
- laboratory at diagnosis or after supportive pre-treatment Creatinine \< 2 mg/dl Uric Acid \< 8 mg/dl Bilirubin \< 1.5 mg/dl ALA, ASA,AP \< 2.5 x ULN
Exclusion
- severe second diseases (e.g. renal failure, cardiomyopathy etc., not caused by leukemia) that exclude treatment according to the protocol
- severe psychiatric illness or other circumstances which may compromise cooperation
- active second neoplasia
- clinical signs of life threatening infections or bleeding, uncontrollable prior to chemotherapy
Key Trial Info
Start Date :
February 1 1997
Trial Type :
INTERVENTIONAL
End Date :
June 1 2003
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00199095
Start Date
February 1 1997
End Date
June 1 2003
Last Update
March 20 2023
Active Locations (1)
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1
University Hospital, Medical Dept. II
Frankfurt, Germany, 60590