Status:
COMPLETED
Efficacy of Pre- and Post-Operative Oral Dextromethorphan
Lead Sponsor:
Khon Kaen University
Conditions:
Efficacy of Dextromethorphan
Morphine Consumption
Eligibility:
FEMALE
30-60 years
Phase:
NA
Brief Summary
We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. Our aim was to compare the analgesic effect...
Detailed Description
One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group...
Eligibility Criteria
Inclusion
- women aged between 30 and 60, with an ASA physical status of I or II, undergoing elective total abdominal hysterectomy under general anesthesia.
Exclusion
- Women with a history of significant renal or hepatic impairment, allergy to any of the study medications, antitussive or NSAID use (48 hours or 1 week, respectively) before surgery, chronic pain and regular analgesic use, were excluded. Patients taking medications that could interact with dextromethorphan, including quinidine, flecainide, mexiletine, fluoxetine, amitriptyline, nortriptyline, and propafenone
Key Trial Info
Start Date :
December 1 2002
Trial Type :
INTERVENTIONAL
End Date :
December 1 2003
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00199303
Start Date
December 1 2002
End Date
December 1 2003
Last Update
September 20 2005
Active Locations (1)
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1
Waraporn Chau-in
KhonKaen, KhonKaen, Thailand, 40002