Status:
COMPLETED
Hypertonic Saline 75% vs Mannitol 20%
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Brain Tumor
Tumor, Brain
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the effect of Hypertonic Saline 7.5% vs Mannitol 20% on brain bulk (using a 4 point scale), intracranial pressure (subdural catheter)and the changes on serum a...
Detailed Description
Raised intracranial pressure occurs following an expansion of an intracranial mass e.g. hematoma or brain tumor and if left untreated, can lead to brain ischemia, stroke and death. Strategies for red...
Eligibility Criteria
Inclusion
- ASA physical status I - 3.
- Age \>18 years.
- Scheduled for elective craniotomies for supratentorial brain tumour resection.
- Written informed consent.
Exclusion
- Within the past six months, a history of unstable angina pectoris and/or having a myocardial infarction.
- Electrocardiogram abnormalities indicating severe ischemia.
- Congestive heart failure.
- Glasgow coma sore \< 9
- Refusal to participate or refusal to agree to randomization.
- Known renal failure
- Known poorly controlled diabetes.
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
End Date :
April 1 2007
Estimated Enrollment :
162 Patients enrolled
Trial Details
Trial ID
NCT00199511
Start Date
January 1 2005
End Date
April 1 2007
Last Update
November 6 2018
Active Locations (1)
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1
University Hospital LHSC
London, Ontario, Canada, N6A5A5