Status:
COMPLETED
Autologous Stem Cell Transplantation in Acute Myocardial Infarction
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
University of Oslo
Ullevaal University Hospital
Conditions:
Acute Anterior Wall Myocardial Infarction
Eligibility:
All Genders
40-75 years
Phase:
PHASE2
Brief Summary
Objectives Intracoronary transplantation of different cell populations have been used in acute myocardial infarction (AMI) with promising results. The primary objective of the ASTAMI study is to test...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- age 40-75 years
- anterior wall AMI with 120-720 minutes from onset of symptoms to PCI
- ST elevation on ECG according to WHO criteria
- angiographically significant stenosis on LAD proximal to the second diagonal branch
- successful PCI with stenting of culprit lesion
- hypokinetic, akinetic or dyskinetic segments assessed by echocardiography in a standard 16 segment model and
- CK-MB above 3 times upper reference value.
- Exclusion criteria:
- previous MI with established significant Q-waves on ECG
- cardiogenic shock
- permanent pacemaker or other contraindication to MRI
- stroke with significant sequela
- short life expectancy due to extra cardiac reason
- uncontrolled endocrinological disturbance
- HIV and/or HBV/HCV positive serology
- mental disorder or other condition which interferes with patient possibility to comply with the protocol.
Exclusion
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
End Date :
May 1 2006
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00199823
Start Date
September 1 2003
End Date
May 1 2006
Last Update
July 6 2011
Active Locations (1)
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1
Rikshospitalet-Radiumhospitalet HF
Oslo, Norway, 0027