Status:
TERMINATED
Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.
Lead Sponsor:
Nantes University Hospital
Conditions:
Heavy Proteinuria
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Determine the best strategy for proteinuria lowering in patients with proteinuria \> 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- proteinuria \> 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months
- proteinuria changes \< 50% on 3 separate dosages over 2 months.
- Exclusion criteria:
- age \< 18 or \> 80 years systolic BP \< 110 or ≥ 140 mmHg, serum creatinine \> 250 mmole/L
- serum creatinine increase on ramipril + valsartan \> 20%
- intolerance to ACEI or ARB
Exclusion
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2007
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00200694
Start Date
March 1 2005
End Date
March 1 2007
Last Update
February 4 2009
Active Locations (1)
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1
CHU de Nantes
Nantes, France