Status:
COMPLETED
Expression of Tuberculosis in the Lung
Lead Sponsor:
University of Medicine and Dentistry of New Jersey
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Tuberculosis
Eligibility:
All Genders
18-65 years
Brief Summary
The purpose of this study is to assess lung immune responses in patients with active pulmonary tuberculosis (TB) and in healthy control persons who are exposed to Mycobacterium tuberculosis in househo...
Detailed Description
BACKGROUND: M. tuberculosis infects a third of the world's population, and TB is the leading cause of morbidity and mortality due to a single infectious agent. However, only 5% to 10% of M. tuberculo...
Eligibility Criteria
Inclusion
- TB patients who are 18 to 65 years old
- Clinical and radiographic signs and symptoms consistent with pulmonary TB
- Start date of antituberculous chemotherapy less than 10 days prior to procedures
- Sputum smear positive for acid fast bacilli
- Drug-sensitive, culture-confirmed growth of M. tuberculosis from sputum
- Willing to provide informed consent for participation in bronchoalveolar lavage and venipuncture studies
Exclusion
- TB patients who have HIV-1 coinfection
- History of any chronic medical condition requiring daily medication (including diabetes mellitus, hypertension, chronic infections, renal or cardiac failure, and peptic ulcer disease)
- History of asthma or upper or lower respiratory tract infection within 2 months of the study
- Hemoglobin level less than 10g/dl
Key Trial Info
Start Date :
September 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00201253
Start Date
September 1 2000
End Date
June 1 2008
Last Update
January 26 2015
Active Locations (2)
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1
UMDNJ-New Jersey Medical School
Newark, New Jersey, United States, 07103
2
Instituto Nacional de Enfermedades Respiratorias (INER)
Mexico City, Mexico