Status:
COMPLETED
Histoblood Group Antigens as a Risk Factor of Asthma
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Asthma
Lung Diseases
Eligibility:
All Genders
18-75 years
Brief Summary
This study will evaluate the link between blood group antigens and asthma exacerbations.
Detailed Description
BACKGROUND: The purpose of this study is to explore the role of histoblood group antigens in virus-induced asthma exacerbations. These antigens (ABH and Lewis) decorate O- and N-linked glycans on muc...
Eligibility Criteria
Inclusion
- Diagnosis of asthma, as confirmed by methacholine responsiveness less than 8 mg/mL
- History of asthma exacerbation in the 2 years prior to study entry requiring treatment with oral corticosteroids
Exclusion
- Cigarette smoking in the 10 years prior to study entry or total pack per year history greater than 10
- History of asthma exacerbations requiring treatment with oral corticosteroids since age 12 (control group)
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT00201266
Start Date
July 1 2005
Last Update
March 13 2013
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143