Status:
UNKNOWN
Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial.
Lead Sponsor:
University Hospital, Linkoeping
Conditions:
Migraine
Eligibility:
FEMALE
18-45 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to determine whether transdermally administered 17-beta estradiol sequentially could reduce the number of, and severity of, menstrual migraine attacks.
Detailed Description
During the fertile ages, migraine is more common in women than in men (3:1). Hormonal factors has been proposed to affect this difference and it has been shown that a rapid decrease in serum concentra...
Eligibility Criteria
Inclusion
- Migraine only during the menstrual period
- Migraine attacks each menstrual period during the last year
- Regular menstrual cycle
Exclusion
- Migraine other times than during the menstrual period
- Use of hormonal contraceptives (other than depo-provera)during the last three months.
- Depo-provera injection the last year
- History of Thrombo-embolism
- Liver disease
- History of malignancy
- Breast-feeding during the last two months
- Abortion/miscarriage during the last two months
- Pregnancy
Key Trial Info
Start Date :
October 1 2001
Trial Type :
INTERVENTIONAL
End Date :
July 1 2005
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00204074
Start Date
October 1 2001
End Date
July 1 2005
Last Update
December 29 2005
Active Locations (1)
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1
Division of Obstetrics & Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences
Linköping, Sweden, SE-58185