Status:
COMPLETED
Effect of Increased Convective Clearance by On-Line Hemodiafiltration on All Cause Mortality in Chronic Hemodialysis Patients
Lead Sponsor:
Amsterdam UMC, location VUmc
Collaborating Sponsors:
UMC Utrecht
Medical Center Alkmaar
Conditions:
End-stage Renal Disease
Cardiovascular Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to compare the effect of low flux hemodialysis with online hemodiafiltration on all cause mortality and a combination of cardiovascular morbidity and mortality in chronic ...
Detailed Description
Today, an increasing number of patients with chronic renal failure (CRF) is treated with (on-line) hemodiafiltration (HDF). This practice is based on the assumption that the high incidence of cardiova...
Eligibility Criteria
Inclusion
- Patients treated by HD 2 or 3 times a week, for at least 2 months
- Patients able to understand the study procedures
- Patients willing to provide written informed consent
Exclusion
- Current age \< 18 years
- Treatment by HDF or high flux HD in the preceding 6 months
- Severe incompliance (severe non-adherence to the dialysis procedure and accompanying prescriptions, especially frequency and duration of dialysis treatment and fluid restriction)
- Life expectancy \< 3 months due to non renal disease
- Participation in other clinical intervention trials evaluating cardiovascular outcome
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
715 Patients enrolled
Trial Details
Trial ID
NCT00205556
Start Date
June 1 2004
End Date
January 1 2011
Last Update
January 21 2011
Active Locations (29)
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1
Dr Georges-L. Dumont Regional Hospital
Moncton, New Brunswick, Canada
2
Centre Hospitalier de L'Université de Montreal, Hopital Notre Dame
Montreal, Canada, H2L 4M1
3
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands, 5200 ME
4
Medisch Centrum Alkmaar
Alkmaar, Netherlands, 1815 JD