Status:
UNKNOWN
Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage. Micorglia activation wil...
Detailed Description
Glutamate and aspartate have been identified as the major excitatory neurotransmitters in the central nervous system. A massive increase in the release of these excitatory amino acids (EEA) has been d...
Eligibility Criteria
Inclusion
- 1\. Traumatic Brain Injury 2. Age: 18-70 years 3. Haemodynamic and respiratory stable
Exclusion
- 1\. Penetrating Skull Damage 2. Pregnancy 3. Hb \< 6,5 mmol/l unless patient is known to have no history of cardiovascular disease, in which case a Hb \< 5,5 mmol/l, will be the exclusion criterion 4. pH \< 7,1 at initial arterial blood analysis 5. Previous neurotrauma 6. Current exposure to radiation in the workplace, or history of participation in nuclear medicine procedures, including research protocols 7. Condition which would exclude a clinical MR scan (e.g. pacemaker, shrapnel, metallic prosthesis)
Key Trial Info
Start Date :
May 1 2001
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00205582
Start Date
May 1 2001
End Date
December 1 2004
Last Update
November 4 2005
Active Locations (1)
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1
VU University Medical Centre
Amsterdam, Netherlands, 1081 HV