Status:
COMPLETED
Microglia Activation in Schizophrenia
Lead Sponsor:
Amsterdam UMC, location VUmc
Collaborating Sponsors:
UMC Utrecht
Conditions:
Schizophrenia
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
Patients with schizophrenia have volume loss in gray matter. This study is designed to evaluate whether their is microglia activation in schizophrenia using \[11C\](R)-PK11195 PET.
Detailed Description
Schizophrenia is a complex and chronic disease that affects different aspects of cognition and behaviour, including attention, perception, thought processes, emotion and volition. Schizophrenia is a b...
Eligibility Criteria
Inclusion
- Schizophrenia according to DSM-IV criteria confirmed by a diagnostic interview (CASH, only for patients) within the first 5 years after initial diagnosis
- Male and Females
- Good physical or mental (controls) Health which will be evaluated with medical history, a physical examination and screening laboratory tests (see appendix 1).
- Age between 18 and 40 years (10 patients and 10 controls)
- Mini Mental State score \>27 .
- Written informed consent of the subject.
- Hb must be \>8 mmol \\ litre at the time of the screening.
Exclusion
- Previous neurotrauma with loss of consciousness
- Any clinical significant abnormality of any clinical laboratory test, including drug screening.
- Any subject who has received any investigational medication within 30 days prior to the start of this study, or who is scheduled to receive an investigational drug.
- any other major current psychiatric diagnosis on axis-1 of DSM-IV (patients)
- History of psychiatric or neurological illness (controls)
- History of psychiatric or neurological illness in first-degree relatives (controls)
- History of alcohol and/or drug abuse (DSM-IV criteria)
- Blood donation within 3 months before the scan day
- Claustrophobia
- Metal objects in or around the body (braces, pacemaker, metal fragments); Pregnancy
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00205608
Start Date
January 1 2004
End Date
December 1 2007
Last Update
June 28 2010
Active Locations (1)
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1
VU University Medical Center
Amsterdam, Amsterdam, Netherlands, 1081 HV