Status:

COMPLETED

Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis

Lead Sponsor:

Wake Forest University

Collaborating Sponsors:

Zambon SpA

Conditions:

Chronic Bronchitis

Eligibility:

All Genders

18-75 years

Phase:

PHASE2

Brief Summary

This is a randonmized, masked, placebo-controlled parallel group, clinical trial to evaluate the effects of three different doses of N-acetyl L-cysteine (NAC) and placebo on patient safety and on phys...

Eligibility Criteria

Inclusion

  • Smokers (past or current,20 pack years) with diagnosis of chronic bronchitis
  • expectorate sputum daily
  • FEV1 of 40-70%
  • understand and fill out questionnaire daily

Exclusion

  • other investigational within 30 days
  • change in smoking habit within 6 months
  • pulmonary diagnosis other that chronic bronchitis
  • significant renal, cardiac, hepatic or endocrine diseases
  • psychiatric disorder or evidence of alcoholism or drug abuse within year

Key Trial Info

Start Date :

January 1 1997

Trial Type :

INTERVENTIONAL

End Date :

March 1 2000

Estimated Enrollment :

240 Patients enrolled

Trial Details

Trial ID

NCT00205647

Start Date

January 1 1997

End Date

March 1 2000

Last Update

November 6 2017

Active Locations (1)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (1 locations)

1

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States, 27157