Status:
COMPLETED
Tandem High Dose Melphalan Versus Triple Intermediate Dose Melphalan and Stem Cell Transplantation in Induction Phase and Prednisolone/IFN Versus IFN in Maintenance Therapy
Lead Sponsor:
Austrian Forum Against Cancer
Conditions:
Multiple Myeloma
Eligibility:
All Genders
19-70 years
Phase:
PHASE3
Brief Summary
This is an international,multicenter, prospective, open, double randomised and controlled phase III study to compare the therapeutic efficacy of tandem high dose Melphalan versus triple intermediate d...
Detailed Description
Patients will be enrolled into this protocol before start of Induction therapy which consists of 3 cycles or VAD with a 4 week interval followed by 1 cycle of IEV after which stem cell harvesting is p...
Eligibility Criteria
Inclusion
- Patients with newly diagnosed multiple myeloma of either IgG, IgG, IgD, IgE, IgM (but excluding Waldenstöm´s macroglobulinemia) lambda of kappa light chain, low-secretory, non-secretory disease or plasma cell leukemia
- Performance status of 0, 1, 2, or 3
- Patients not pre-treated with cytostatic drugs
- Patients who clearly require treatment (usually Durie and Salmon stage II or III)
- Patients in stage I who are symptomatic and/or show progression of their disease
- Patients must have an anticipated life expectancy of at least 3 months
- Patients must have adequate organ function
- Patients must have had a minimum recovery period of 2 weeks following any major surgical procedure before entry into this study
- Patients must be between 19 and 70 years of age, also it is understood that most of the patients above 65 will not be eligible because of poor performance status or multimorbidity
- Women of childbearing potential must have a negative pregnancy test and must take adequate precautions to prevent pregnancy during treatment
- Patients must have signed an informed consent
Exclusion
- Patients with more than 3 irradiation fields
- Patients presenting initially with one of the following conditions:
- Extramedullary plasmacytoma or solitary plasmacytoma
- Monoclonal gammopathy of undetermined significance
- Smouldering myeloma
- Patients with an irreversible performance status of 4
- Medical of psychiatric conditions that compromise the patient´s ability to give informed consent or complete the study
- Patients with congestive heart failure, NYHA III, IV
- Known HIV positivity
- Known intolerance to any of the study drugs or components
- Acute infection requiring systemic antibiotics at study entry until fully resolved
- Patients with any underlying medical condition which cannot be adequately controlled
- Patients with second primary malignancies (with the exception of cervical carcinoma in situ and non-melanoma skin malignancies) are not eligible unless the patient has been disease-free for at least five years
Key Trial Info
Start Date :
March 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT00205764
Start Date
March 1 1999
End Date
October 1 2009
Last Update
November 25 2013
Active Locations (1)
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1
Wilhelminenspital, 1st Medical Department-center for oncology and hematology
Vienna, Austria, 1160