Status:
COMPLETED
The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity
Lead Sponsor:
Affective Neuroscience Laboratory
Collaborating Sponsors:
Massachusetts General Hospital
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-64 years
Phase:
PHASE1
Brief Summary
The purpose of the study is to evaluate the effects of a single-dose of Wellbutrin XL (bupropion hydrochloride) on reward processing.
Detailed Description
A cardinal feature of Major Depressive Disorder is anhedonia, which is a lack of pleasure in normally enjoyable activities. In order to understand reward processing in depressed individuals it is also...
Eligibility Criteria
Inclusion
- Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse)
- Non-Smoker
- Right-handed (Chapman and Chapman 1987)
- Ability to provide informed consent
Exclusion
- Predisposition to seizure (e.g. family history of a seizure disorder, history of head trauma) or current use of medications that lower the seizure threshold
- History or current diagnosis of anorexia or bulimia
- Alcohol or substance abuse within the past year
- Current usage of Wellbutrin or Zyban or other drugs that contain bupropion
- Recent discontinuation of alcohol or sedatives (including benzodiazepines)
- Use of (in the last 2 weeks) medications that may have antidepressant properties (ex. some herbal supplements)
- Known allergies to bupropion
- Currently lactating, pregnant or believe you are likely to be pregnant (enrolled subjects who are not using reliable contraception and have engaged in sexual intercourse since their last menstrual period will be given a self-administered pregnancy test.)
- Left-handed/ambidextrous
- Evidence of neurological illness
- Serious suicide or homicide risk
- Concomitant medications other than those listed in the exclusion criteria will be considered on an individual basis. Oral contraceptives will be allowed.
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2007
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00205946
Start Date
April 1 2005
End Date
July 1 2007
Last Update
December 6 2007
Active Locations (2)
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1
The Depression Clinical and Research Program, Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Affective Neuroscience Laboratory, Department of Psychology, Harvard University
Cambridge, Massachusetts, United States, 02138