Status:
COMPLETED
The Role of Oxygen in the Management of Dyspnoea in Advanced Cancer
Lead Sponsor:
Bayside Health
Collaborating Sponsors:
Peter MacCallum Cancer Centre, Australia
Bethlehem Griffiths Research Foundation
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine the effect that oxygen has when administered to patients complaining of shortness of breath, where the underlying cause of this symptom is advanced cancer. Th...
Detailed Description
Dyspnoea is a devastating symptom in patients with advanced cancer. Management strategies are limited and include behavioural therapies such as relaxation, and pharmacological therapies such as opioid...
Eligibility Criteria
Inclusion
- Patients who have dyspnoea mainly due to advanced cancer. Patients with a history of COAD will be eligible for participation in this study as long as the main mechanism of current dyspnoea is related to tumor.
- intensity of dyspnoea of at least 3 on a 0-10 visual analogue scale at the time of treatment.
- Regular Bronchodilators and corticosteroids and other adjuvant medications for dyspnoea will be allowed to continue during the study. Inhaled bronchodilator steriods may not be used during the study period.
- Patients may be receiving regular oral or parenteral opioids and opioid dose must be stable for 24 hours.
- Patients must have normal cognitive status defined as normal state of arousal and absence of obvious clinical findings of confusion, memory or concentration deficit according to Blessed Orientation Memory \& Concentration mental status examination (score\<10).
- Patients must be 18 years of age or older.
- Patients must have no contraindications to oxygen.
- Patients must sign written informed consent.
Exclusion
- Patients who have evidence of acute respiratory distress.
- Patients who are currently oxygen dependent
- Patients who refuse to participate or are deemed incapable of completing the research.
Key Trial Info
Start Date :
November 1 2000
Trial Type :
INTERVENTIONAL
End Date :
March 1 2005
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00206609
Start Date
November 1 2000
End Date
March 1 2005
Last Update
September 21 2005
Active Locations (1)
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1
The Alfred Hospital
Prahran, Victoria, Australia, 3004