Status:
COMPLETED
The Effect of Imipramine on Early Information Processing
Lead Sponsor:
Birte Glenthoj
Collaborating Sponsors:
University of Copenhagen
Glostrup University Hospital, Copenhagen
Conditions:
Healthy Volunteers
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
We wanted to compare the relation of two different psychophysiological paradigms (PrePulse Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we wanted to test ...
Detailed Description
Schizophrenic patients exhibit impairments in filtering of sensory information, as can be assessed by use of prepulse inhibition (PPI) of the acoustic startle response and P50 suppression paradigms. I...
Eligibility Criteria
Inclusion
- Male subjects
- Good Physical and Mental Health meeting criteria "never mentally ill", which will be evaluated with a medical history checklist, ECG
- Non smokers
Exclusion
- Current use of any medication
- Any subject who has received any investigational medication within 30 days prior to the start of this study
- History of neurologic illness
- History of psychiatric illness in first-degree relatives, evaluated with DSM-IV criteria
- History of alcohol and drug abuse. Positive urine screening for amphetamine, cocaine, cannabis, or ecstasy.
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00206999
Start Date
September 1 2004
End Date
January 1 2006
Last Update
September 20 2011
Active Locations (1)
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1
Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Center Glostrup
Glostrup Municipality, Denmark, DK-2600