Status:
COMPLETED
Selenium, as Sodium Selenite, in the Treatment of Septic Shock
Lead Sponsor:
Centre Hospitalier de Meaux
Collaborating Sponsors:
Ministry of Health, France
Conditions:
Septic Shock
Severe Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Septic shock is a frequent syndrome with a 45% mortality rate despite intensive care unit (ICU) care, where free radicals may play a key role, and a \>40% decrease in plasma selenium concentration is ...
Detailed Description
Septic shock - an uncontrolled systemic host response to invasive infection -, leading to multiple organ failure, is a public health issue because of its frequency (\> 1/1000 inhabitants per year), it...
Eligibility Criteria
Inclusion
- Hospitalization in ICU
- Severe documented infection
- Ventilation
- Circulatory failure requiring high dose of catecholamine
- IGS II score \>25 at inclusion
- Informed written consent
Exclusion
- Pregnancy
- End phase chronic disease
- Limitation of care
- Shock due to an urinary infection without bacteriemia
- Peritonitis related to peritoneal dialysis or trauma
- Preliminary circulatory failure
- Participating to another clinical trial
Key Trial Info
Start Date :
January 1 2002
Trial Type :
INTERVENTIONAL
End Date :
January 1 2005
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00207844
Start Date
January 1 2002
End Date
January 1 2005
Last Update
September 21 2005
Active Locations (7)
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1
Service de Réanimation - Centre Hospitalier Victor Dupouy
Argenteuil, France, 95107
2
Service de Réanimation Polyvalente - CH de Châlons
Châlons-en-Champagne, France, 51000
3
Service de Réanimation Médicale - Hôpital Raymond Poincaré
Garches, France, 92380
4
Service de Réanimation - HIA Desgenettes
Lyon, France, 69275