Status:
COMPLETED
Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia
Lead Sponsor:
Creighton University
Collaborating Sponsors:
AstraZeneca
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
19-65 years
Phase:
PHASE4
Brief Summary
It is hypothesized that the atypical antipsychotic, Seroquel, will cause significant reduction in drug and alcohol cravings in patients with schizophrenia and comorbid cocaine and/methamphetamine depe...
Detailed Description
Schizophrenia is a serious mental illness that afflicts approximately 1% of the population (1). Often these patients have comorbid cocaine and amphetamine dependence, which increases the severity of p...
Eligibility Criteria
Inclusion
- Ages 19 - 65.
- Diagnosis of schizophrenia or schizoaffective disorder with comorbid cocaine and/or amphetamine abuse/dependence as confirmed by Structured Clinical Interview for DSM-IV.
- Comorbid diagnoses of depression, anxiety and/or personality disorders are permitted.
- Ability to provide signed informed consent.
- Stable general medical health.
Exclusion
- Dangerous to self or others.
- Pregnancy, inability or unwillingness to use approved methods of birth control.
- Inability or unwillingness to provide signed informed consent.
- Diagnosis of bipolar disorder, primary major depressive disorder (As major Axis I diagnosis).
- Inability to attend outpatient research clinic.
- Medical conditions, which would preclude use of Seroquel.
- Absolute need for ongoing treatment with antipsychotic other than Seroquel.
- Medical instability defined as likelihood of needing to change prescription medication during the course of the study.
- Patients currently taking quetiapine or risperidone.
- Patients with unsuccessful treatment with quetiapine or risperidone.
- Subjects with a HAM-D score of ≥20 at screening.
Key Trial Info
Start Date :
November 1 2003
Trial Type :
INTERVENTIONAL
End Date :
December 1 2005
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00208143
Start Date
November 1 2003
End Date
December 1 2005
Last Update
December 13 2007
Active Locations (1)
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1
Creighton University Psychiatry and Research Center
Omaha, Nebraska, United States, 68131