Status:
COMPLETED
Characterizing Psychological Consequences of Childhood Trauma
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-45 years
Brief Summary
This study will characterize the mental health consequences of early-life trauma.
Detailed Description
This primary goal of this Center is to characterize the neurobiological consequences of early-life trauma. The Center comprises 6 projects that include human subjects. Human subjects are recruited thr...
Eligibility Criteria
Inclusion
- For participants assigned to the MDD groups: current DSM-IV diagnosis of MDD
- For participants assigned to the early-life stress group: repeated (once per month or more for at least year) sexual or physical abuse before the age of 13 years by a perpetrator at least 5 years older at the time
- For female participants: regular menstrual cycle and assessment in the early follicular phase as verified by sex steroid measures
Exclusion
- Meets DSM-IV criteria for a gender identity disorder
- For all participants assigned to non-MDD groups: DSM-IV diagnosis of current MDD
- For all participants assigned to the group without early-life stress: major stress experiences before the age of 12 years, such as separation from parents, neglect, parental loss, accidents, severe illness, or natural disaster
- Significant medical illness, such as gastrointestinal, neurological, hormonal, heart, lung, kidney, liver, immunological or hematological disease, organic brain disease, or cancer as determined by history, physical examination, ECG, and laboratory tests
- Pregnant or breastfeeding
- Past or current presence of psychotic symptoms or bipolar disorder
- Current presence of psychoactive substance abuse/dependency or eating disorders
- Currently taking hormonal medication
- Taking psychotropic medication within 4 weeks of study entry
- General exclusion criteria for PET and fMRI
Key Trial Info
Start Date :
January 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
113 Patients enrolled
Trial Details
Trial ID
NCT00209105
Start Date
January 1 2005
End Date
March 1 2011
Last Update
November 13 2013
Active Locations (1)
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1
General Clinical Research Center at Emory University Hospital
Atlanta, Georgia, United States, 30322