Status:
COMPLETED
Citrate Versus Heparin Anticoagulation in Continuous Venovenous Hemofiltration
Lead Sponsor:
Free University Medical Center
Collaborating Sponsors:
Dirinco B.V.
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this study is to compare citrate regional anticoagulation with systemic heparinization in continuous venovenous hemofiltration. The investigators' hypothesis is, that regional citrate a...
Detailed Description
Acute renal failure occurs in about 20% of critically ill patients and is associated with increased morbidity and mortality, in spite of modern renal replacement techniques. The latter include continu...
Eligibility Criteria
Inclusion
- Patients admitted on the Intensive Care Unit (ICU) requiring continuous venovenous hemofiltration.
- No high bleeding risk. A high bleeding risk is defined as a platelet count below 40 x 10\^9/L or APTT of more than 60 seconds or a PT-INR of more than 2.0 or a recent major bleeding or significant active bleeding i.e. requirement for more than two units of packed red blood cells as a transfusion within 24 hours of initiation of CVVH.
Exclusion
- Less than 18 or over 80 years of age.
- Patients administered heparin or coumarins for other reasons will also be excluded.
- Patients with a HIT in known history will also be excluded.
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
139 Patients enrolled
Trial Details
Trial ID
NCT00209378
Start Date
May 1 2005
End Date
May 1 2012
Last Update
April 4 2013
Active Locations (9)
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1
Medical Center Alkmaar
Alkmaar, Netherlands, 1815 JD
2
Slotervaart Ziekenhuis
Amsterdam, Netherlands, 1066 EC
3
St Lucas Andreas Ziekenhuis
Amsterdam, Netherlands
4
Vrije Universiteit Medical Center
Amsterdam, Netherlands