Status:
COMPLETED
A Pharmacokinetic Evaluation Study in Healthy Volunteers
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Healthy
Phase:
PHASE1
Brief Summary
The purpose of this trial is to characterize the pharmacokinetics of INS37217 following intravenous, intranasal, and inhalation administration and to calculate the relative bioavailability of INS37217...
Eligibility Criteria
Inclusion
- Are current nonsmokers or previous smokers who have not smoked within 6 months and who do not have greater than or equal to a 10 pack-year history of tobacco use
- Are within 20% of their ideal body weight
- Are healthy on the basis of a pre-trial physical examination
Exclusion
- History or suspicion of recent alcohol, barbiturate, amphetamine or narcotic abuse or a positive urine drug test at study screening
- History of cardiac arrhythmias, any pathological abnormality on the ECG, bronchospasm, diabetes mellitus, thyrotoxicosis, Parkinsonism, asthma, COPD or cardiovascular disease significant drug allergy
- Subject with a physical obstruction in the nose
- Use of concomitant medication other than hormonal contraceptives and multi-vitamins
- Subjects with a current upper respiratory illness or infection for the 2 weeks prior to screening or any chronic respiratory illness
Key Trial Info
Start Date :
April 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2003
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00210093
Start Date
April 1 2003
End Date
May 1 2003
Last Update
October 16 2015
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