Status:
COMPLETED
A Pilot Study of the Treatment of Central Serous Chorioretinopathy With Ketoconazole
Lead Sponsor:
Manhattan Eye, Ear & Throat Hospital
Collaborating Sponsors:
LuEsther T. Mertz Retinal Research Center
Conditions:
Chronic Central Serous Chorioretinopathy
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine the effect of an adrenocorticoid antagonist (ketoconazole), 600 mg per day for 4 weeks, in the treatment of patients with central serous chorioretinopathy (CS...
Detailed Description
A complete ophthalmic evaluation and tests: autofluorescence and Fluorescein angiography, Color Fundus Photography, OCT, including liver and adrenal functions and pregnancy test, if applicable will be...
Eligibility Criteria
Inclusion
- Age less than 60 years
- Must have clinical signs of CSC with leakage from the level of the RPE during fluorescein angiography and neurosensory detachment documented by optical coherence tomography (OCT).
- Be able to return for all study visits for 3 months' duration.
- Be able to provide written informed consent
- Must have sufficiently clear media to allow for adequate fundus photography
Exclusion
- Have choroidal neovascularization.
- Have any evidence of clinically significant intraocular inflammation, angioid streaks, presumed ocular histoplasmosis syndrome, or other precursor of choroidal neovascularization.
- Have additional eye disease that compromises the visual acuity of the study eye.
- Are receiving any systemic steroid therapy
- Have any significant medical history
- Have a history of severe hypersensitivity reaction to any of the dyes or the drug used in the study.
- Have any history of ocular conditions that may mimic CSC
- Are pregnant
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT00211393
Start Date
May 1 2005
End Date
April 1 2008
Last Update
October 25 2012
Active Locations (1)
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1
Manhattan Eye, Ear & Throat Hospital
New York, New York, United States, 10021