Status:
TERMINATED
Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
Abbott
Conditions:
Pathological Gambling
Obsessive Compulsive Disorder
Eligibility:
All Genders
18-55 years
Brief Summary
This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls.
Detailed Description
This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls. Health...
Eligibility Criteria
Inclusion
- Male or female adults diagnosed with pathological gambling or obsessive compulsive disorder aged 18-55.
- Subject has signed an informed consent form
- Must provide contact information
- Must be in generally good health
- Must be willing and able to read written instructions and complete scales
- Must be English speaking
- In the opinion of the investigator, the subject is capable of complying with all study procedures
- Pathological Gamblers only:
- Current diagnosis of pathological gambling, supported by DSM-IV SCI-PG
- Must score ≥ 5 on SOGS
- Must score ≥ 2 on item number 1 on the G-SAS
- Subjects must have a severity score of ≥ 4 (moderately ill) on the Clinical Global Impressions Scale - Severity (CGI-S)
- Must score ≥ 10 on questions 1-5 on PG-Y-BOCS
- Must score ≤ 15 on YMRS
- Must have gambled once within past 2 weeks of Screening Visit.
Exclusion
- Subjects with a primary diagnosis of schizophrenia, personality disorder, or other psychotic disorders
- Subjects with a primary diagnosis of an Axis I disorder that may require intervention
- Must not score \>24 on the Montgomery-Asberg Depression Rating Scale (MADRS) (pathological gamblers only)
- Subjects who live in a restrictive environment
- Subjects with a current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine
- Subjects reporting a history of drug and/or alcohol dependence or abuse; subjects who report occasional drug use in the past will be discussed by a panel (consisting of Dr. Gilbert, Dr. Fan and Dr. Bartz), and will be considered for participation on a case by case basis
- Subjects who have used psychotropic medications in the past week to six weeks (depending on the medication)
- Subject has a positive drug urine screen
- Female subjects who are pregnant
- Subjects who report a history of severe liver, heart, or kidney disease because these conditions are associated with neurological sequella
- Employees of the investigator or study center or their families
- Finally, subjects who do not satisfy the following criteria will be excluded because they will be unable to undergo the MRI procedure. Specifically, subjects will be excluded who have:
- a pacemaker
- any implanted metallic chips in their head
- ever worked around a metal lathe or had a shrapnel (war or gun shot) wound/injury
- an implanted neuro-stimulatory or infusion/insulin pump
- any devices placed in their blood vessels
- any metal in/on their body
- kidney disease
- sickle-cell or hemolytic anemia
- claustrophobia
- any metallic tattoos
- any body piercing that cannot be removed
- dental braces
- any permanent make-up
- any cardiac stints
Key Trial Info
Start Date :
November 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT00211822
Start Date
November 1 2004
End Date
December 1 2010
Last Update
July 14 2011
Active Locations (1)
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1
Mount Sinai School of Medicine
New York, New York, United States, 10029