Status:
COMPLETED
Japan-Working Groups of Acute Myocardial Infarction for the Reduction of Necrotic Damage by ANP
Lead Sponsor:
National Cerebral and Cardiovascular Center, Japan
Collaborating Sponsors:
Japan Cardiovascular Research Foundation
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
20-79 years
Phase:
NA
Brief Summary
To evaluate whether ANP as an adjunctive therapy for AMI reduces myocardial infarct size and improves regional wall motion.
Detailed Description
The benefits of percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) are limited by reperfusion injury. In animal models, atrial natriuretic peptide (ANP) reduces infarct size...
Eligibility Criteria
Inclusion
- Age 20-79 years
- Chest pain of more than 30 min
- 0.1 mV ST-segment elevation in 2 contiguous ECG leads
- Admission to hospital within 12 h of symptom onset
- First episode of AMI
- Candidates for PCI
Exclusion
- History of old myocardial infarction
- Left main coronary artery stenosis
- Severe liver and/or kidney dysfunction
- Suspected aortic dissection
- History of coronary artery bypass graft
- History of allergic response to drugs
- Severe hypovolemia
- Right ventricular infarction
Key Trial Info
Start Date :
October 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2005
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT00212056
Start Date
October 1 2001
End Date
December 1 2005
Last Update
November 1 2007
Active Locations (1)
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1
National Cardiovascular Center
Suita, Osaka, Japan, 544-0024