Status:
COMPLETED
L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
Heart Transplantation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction...
Eligibility Criteria
Inclusion
- Male (\> 18 years old) stable heart transplant recipient for at least 6 weeks
- Stable treatment for at least 3 months
- Sedentary people
Exclusion
- Unstable cardiac pathology
- Obesity (IMC \> 40)
- Participation in another study in the last month
- Chronic renal failure (creatinine clearance \< 20 ml/min)
- Renal transplantation
- Diabetes
- Impossibility to practice exercise test
- Nitrate therapy
Key Trial Info
Start Date :
February 1 2004
Trial Type :
INTERVENTIONAL
End Date :
December 1 2004
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00213915
Start Date
February 1 2004
End Date
December 1 2004
Last Update
December 22 2025
Active Locations (3)
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1
Institut de Physiologie
Strasbourg, France, 67091
2
Service de Chirurgie Vasculaire
Strasbourg, France, 67091
3
Service des Explorations Fonctionnelles Respiratoires et de l'Exercice
Strasbourg, France, 67091