Status:
WITHDRAWN
Vascular Pathophysiology in Obstructive Sleep Apnea
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Obstructive sleep apnea (OSA) is a medical problem whose importance is increasing in recognition and awareness. The National Commission on Sleep Disorders estimates that 15 million Americans have OSA,...
Eligibility Criteria
Inclusion
- Patients with Sleep Disordered Breathing:
- Significant obstructive sleep apnea as verified by complete overnight polysomnography with apnea-hypopnea index (AHI) \> 10 events per hour.
- Fasting total cholesterol \< 240 mg/dL
- Fasting blood glucose \< 120 mg/dL
- Control subjects:
- Free of sleep disordered breathing verified by complete overnight polysomnography or oxygen desaturation screening (AHI \< 5 events per hour)
- Fasting total cholesterol \< 240 mg/dL
- Fasting blood glucose \< 120 mg/dL
Exclusion
- Presence of any cardiovascular diseases or medical conditions that will affect vascular responses (other than sleep apnea)
- Subject taking any vasoactive medications, willing to stop taking vitamins or supplements for study participation
- Current smokers
- History of adverse reaction to allopurinol, acetylcholine, nitroprusside, verapamil or lidocaine
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00214084
Last Update
October 8 2015
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53792