Status:
COMPLETED
Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease
Lead Sponsor:
Boston Children's Hospital
Collaborating Sponsors:
Crohn's and Colitis Foundation
Conditions:
Inflammatory Bowel Disease
Ulcerative Colitis
Eligibility:
All Genders
Up to 18 years
Brief Summary
Isoprostanes are compounds that are produced as a result of oxidative damage to cell membranes. Elevated tissue, serum, and urinary isoprostane levels have been described in a number of inflammatory d...
Detailed Description
Isoprostanes are compounds produced as a result of oxidative damage to cell membranes. Elevated tissue, serum, and urinary isoprostane levels have been described in a number of inflammatory diseases. ...
Eligibility Criteria
Inclusion
- Patients scheduled for endoscopic evaluation (upper endoscopy, colonoscopy or sigmoidoscopy)
- Patients currently completing lactose hydrogen breath tests (LHBT)
Exclusion
- Patients with a previous history of HIV and/or chronic Hepatitis (or active acute hepatitis B or C). Patients will be asked about potential blood borne pathogens at the time of enrollment. No additional blood work or serologic testing outside that obtained for routine care will be required for participation in this study.
- Patients with a documented history of infectious diarrhea (within the past six months): Patients will be asked about previous testing for infectious diarrhea at the time of enrollment. When indicated, subjects will be asked to have primary care providers forward the results of previous testing.
- Patients with active Reactive Airway Disease (RAD)/Asthma.
- Patients with heart disease
- Smokers
- Patients with Connective tissue diseases (Scleroderma, Lupus, etc)
- Patients with Renal Disease
- Subjects must have had recent biochemical studies completed (including CBC, albumin, and ESR) within one month of receipt of sample.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2006
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00215020
Start Date
September 1 2003
End Date
June 1 2006
Last Update
January 27 2016
Active Locations (1)
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1
Children's Hospital
Boston, Massachusetts, United States, 02115