Status:
UNKNOWN
Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Burns
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of the study is to understand the way the body uses amino acids and proteins in burned patient during the time they cannot eat normally. This study aims to understand the metabolism of the...
Detailed Description
The principle sources of plasma free arginine are (i) diet, (ii) release from protein breakdown and (iii) de novo synthesis directly from citrulline and the recycling of orthinine via the urea cycle. ...
Eligibility Criteria
Inclusion
- Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) \>=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of \>15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
- Must be receiving total parenteral nutrition in the course of their treatment.
Exclusion
- Patients with thyroid disease
- Patients who are not hemodynamically stable or show unstable vital signs
- Patients at the stage of major organ failure, e.g. renal and/or liver failure.
Key Trial Info
Start Date :
August 1 1997
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00216970
Start Date
August 1 1997
End Date
December 1 2009
Last Update
August 13 2009
Active Locations (1)
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1
MGH Burn Unit
Boston, Massachusetts, United States, 02114